Test Name | Tumor | Approved Use | Ordered By | Ordering Comment |
Androgen Receptors | Breast | Triple-neg breast cancers | ONC | |
BRAF Mutation | Melanoma | Stage IV melanomas (not I-III) | ONC | |
BRAF Mutation | Lung | Can order if EGFR, EML4, ALK, ROS1 and PD-L1 are negative, and patient is a NON-SMOKER. | ONC | |
BRAF Mutation | Thyroid | Prognostic for papillary carcinoma | ONC ENDOCRINE | |
Breast Cancer Index | Breast | NOT APPROVED | | |
Cancer Type ID | Colon | NOT APPROVED | | |
Cancer Type ID | Tumor of Unknown Primary | NOT APPROVED Test under investigation | | Use clinical data and history to find primary. |
C-Kit Melanoma | Melanoma | Acral and Mucosal melanoma Not for other types | ONC | |
ConfirmMDx | | NOT APPROVED | | Urologists seeking its approval |
Caris Molecular Intelligence | | NOT APPROVED | | |
Double-hit Lymphoma FISH MYC BCL | Lymphoma | Diffuse Large B-cell Lymphoma | ONC HEMEPATH | Only perform if not a typical diffuse large B-cell lymphoma |
Foundation One | | NOT APPROVED | | |
Her2 (IHC) | Breast | Invasive ductal and lobular. | PATH | REFLEX |
Her2 (IHC) | Stomach | Gastric carcinoma | ONC | |
EGFR -> EML4 -> ALK -> ROS-1 (mol) and PD-L1 (IHC) | Lung | LUNG Adeno, adenosquamous and NSCCa-NOS in NON-SMOKERS NOT for squamous or small cell | ONC | ROS-1 must be specified in Tapestry. If all negative, BRAF may be done by ONC request Unstained slides (if core) and block sent to facility, then to Quest. |
EGFR -> EML4 -> ALK -> ROS-1 (mol) and PD-L1 (IHC) | Lung | LUNG Squamous cell ca in NON-SMOKERS NOT for smokers | ONC | ROS-1 must be specified in Tapestry. If all negative, BRAF may be done by ONC request Unstained slides (if core) and block sent to facility, then to Quest. |
EGFR -> EML4 -> ALK (mol) and PD-L1 (IHC) or KRAS -> EGFR -> EML4 -> ALK (mol) and PD-L1 (IHC) | Lung | LUNG Adeno, adenosquamous and NSCCa-NOS in SMOKERS NOT for squamous or small cell; NOT for non-smokers | ONC | Unstained slides (if core) and block sent to facility, then to Quest. KRAS may be ordered up front (KRAS and EGFR are mutually exlcusive) |
GeneStrat EGFR T790M Assay (blood test) | Lung | LUNG Non-small cell ca with acquired EGFR-TKI resistance | ONC | Send test to ARUP |
KRAS, NRAS and BRAF | Colon | COLON metastatic cancer | ONC | |
MRD (Minimal Residual Disease) | Leukemia | LEUKEMIA ALL and AML | ONC | Two purple tops drawn at end of induction period (Day 29). Send one for regular flow cytomery, send other to Univ. of Washington for MRD testing using a 10-marker panel. |
MRP (Mismatch Repair Protein) (IHC) | Colon | COLORECTAL adenocarcinoma | PATH | REFLEX on biopsy. Order on metastasis ONLY if not already done on primary. |
KRAS with Reflex NRAS and BRAF if MRP mutation NEG | Colon | COLORECTAL adenocarcinoma | REGIONAL | Reflex based on MRP result |
KRAS with Reflex NRAS (no BRAF) if MRP mutation POS | Colon | COLORECTAL adenocarcinoma | REGIONAL | Reflex based on MRP result |
MRP (Mismatch Repair Protein) (IHC) | Endometrium | ENDOMETRIAL carcinoma | PATH | Reflex on biopsy |
MRP (Mismatch Repair Protein) (IHC) | Sebaceous | SEBACEOUS lesions other than hyperplasia (patient <65 or with fam hx or signs of Muir-Torre) | DERMPATH | If <65 and no suspicous for Muir-Torre, don't need to send to Cassarino. |
MSI (Microsatellite Instability) | | | GENETICS | |
Oncotype DX | Breast | DCIS From lumpectomy to determine need for radiation | RAD-ONC | |
Oncotype DX | Breast | Invasive duct/lobular ER+ Node- ER+ Her2- Node(1-3)+ NOT if ER- or ER+ Node(>3)+ or ER+ Her2+ | ONC | |
Oncotype DX | Colon | NOT APPROVED | | |
Oncotype DX | Prostate | NOT APPROVED | | |
Oncogenic CSF3R Mutation | Leukemia | CML and atypical CML for patients who might take Ruxolotinib | ONC | |
p16 | Oropharynx | Sqamous carcinoma Not for Oral cavity, laryngeal, nasopharynx or sinonasal primary tumors | PATH | REFLEX |
CMET (IHC) | Stomach | NOT APPROVED | | |
ER beta subunit | Melanoma | NOT APPROVED | | |
1p19q del (FISH) | Brain | Low-grade glioma Not for GBM | NEUROPATH | REFLEX |
|
MGMT | Brain | Low-grade gliomas and GBM | PATH | REFLEX |
IDH1 (IHC) | Brain | Low-grade gliomas and GBM | NEUROPATH | REFLEX |
IDH1 (PCR) | Brain | NOT APPROVED | | |
IDH1/2 | Brain | Low-grade gliomas when IDH1(-) by IHC | NEUROPATH | REFLEX |
PD-L1 (PCR) | Lung | Non-small cell carcinomas | | Order as Other-Outside IHC. In comment, state drug that patient is on (either Opdivo or Keytruda). Scan report into Media tab. |
PD-L1 | Other | After discussion between path and onc | ONC | Gastric (prognostic): Send to Quest, requesting to be sent to Chantilly (test code 94007) |
Prolaris | | NOT APPROVED | | |
TERT | Brain | NOT APPROVED | | |
450K array | Brain | NOT APPROVED | | |