IHC Staining of Carcinomas of Unknown Origin

IHC Staining of Carcinomas of Unknown Origin
TumorPSA or NKX3.1TTF1 or Napsin-AGCDFP-15 or MammaglobinWT-1PAX-8ERCA-125MesothelinCK7CDX2 and/or CK20
Prostate+---------
Lung-+-----+-++-
Breast--+---+--+-+-
Ovarian serous---+++-+++-
Ovarian mucinous-----+-+-+-+-+-+
Pancreas-----+-+-+-+
Stomach-------++--+
Colon--------++

+ = ≥90%, +- = 50%–90%, -+ = 10%–50%, − = ≤10%



Tumor-specific Markers
MelanomaS100, Melan-a, HMB45
SarcomaVim, Actin, Desmin, S100, c-Kit
Squamous CarcinomaCK5/6, p63
Transitional Cell CaUrothelin
Neuroendocrine TumorsChromogranin, CD56, Synaptophysin, TTF-1
KidneyRCC, CD10, PAX-8, Napsin-A
LiverHepar1, CD10, glypican-3
ThyroidTTF-1, Thyroglobulin, PAX-8
AdrenalMelan-A, inhibin
Germ Cell TumorsOCT4, PLaP, HCG, AFP
MesotheliomaCalretinin, Mesothelin, WT-1, D2-40
Annals of Oncology Volume 23, Issue suppl 10pp. x271-x277